Current Issue : October - December Volume : 2020 Issue Number : 4 Articles : 5 Articles
Polygonum hydropiper L. is a traditionally usedmedicinal plant. The present studywas designed\nto explore the Alpha-amylase inhibitory, antioxidant, and antimicrobial activities of Polygonum hydropiper L.\nPolarity-based solvent extracts (n-hexane, acetone, chloroform, methanol, ethanol, and water) of\nPolygonum hydropiper leaves and stem were used. Antioxidant activity was assessed by free radical\nscavenging assay (FRAP) and 2,2-diphenylpicrylhydrazyl (DPPH) free radical scavenging activity\nmethods. Quantitative phytochemical analyses suggested that the stem of Polygonum hydropiper L.\ncontains higher levels of bioactive compounds than its leaves (p < 0.05). The results suggested that\nstem-derived extracts of Polygonum hydropiper L. are more active against bacterial species, including\ntwo Gram-positive and three Gram-negative strains. Moreover, our results showed that the bioactive\ncompounds of Polygonum hydropiper L. significantly inhibit Alpha-amylase activity. Finally, we reported\nthe polarity-based solvent extracts of Polygonum hydropiper L. and revealed that the stem, rather than\nleaves, has a high antioxidant potential as measured by FRAP and DPPH assay with IC50 values of\n1.38 and 1.59 mg/mL, respectively. It may also be deducted from the data that the Polygonum hydropiper\nL. could be a significant candidate, which should be subjected to further isolation and characterization,\nto be used as an antidiabetic, antimicrobial and antioxidant resource in many industries, like food,\npharmaceuticals and cosmetics....
Medicinal plants hold a significant place as alternative treatments available for inflammatory\ndiseases, with many phytoconstituents being frequently tested in vitro for their biological activities.\nIn the current study, we investigated the in vivo anti-inflammatory properties of a novel active gel\nformulation, combining Achillea millefolium and Taxodium distichum essential oils with extracts of\nAesculus hippocastanum seeds and Plantago lanceolata leaves. The toxicity of the obtained extracts and\nvolatile oils was determined using the invertebrate model based on Daphnia magna. Anti-inflammatory\npotential was evaluated by the plethysmometric method onWistar rats, expressed as the inhibition of\nthe inflammatory oedema (%IIO), while the antinociceptive response was determined on NMRI mice,\naccording to the tail-flick latency method. The tested gelâ??s ecacy was similar to the 5% diclofenac\nstandard (maximal %IIO of 42.01% vs. 48.70%, respectively), with the anti-inflammatory eect being\nobserved sooner than for diclofenac. Our active gel also produced a significant prolongation of\ntail-flick latencies at both 60 and 120 min, comparable to diclofenac. Consequently, we can imply that\nthe active constituents present in vivo anti-inflammatory properties, and the prepared gel may be\nsuited for use as an alternative treatment of topical inflammatory conditions....
Apart from its essential oil, Prunus armeniaca L. kernel extract has received only scarce\nattention. The present study aimed to describe the lipid and polyphenolic composition of the\ndichloromethane, chloroform, ethyl acetate, and ethanol extracts on the basis of hot extraction,\nperforming analysis by gas chromatography and high-performance liquid chromatography coupled\nwith mass spectrometry. A total of 6 diacylglycerols (DAGs) and 18 triacylglycerols (TAGs)\nwere detected as being present in all extracts, with the predominance of OLL (dilinoleyl-olein),\nOOL (dioleoyl-linolein), and OOO (triolein), with percentages ranging from 19.0â??32.8%, 20.3â??23.6%,\nand 12.1â??20.1%, respectively. In further detail, the extraction with ethyl acetate (medium polarity\nsolvent) gave the highest signal for all peaks, followed by chloroform and dichloromethane (more\napolar solvent), while the extraction with ethanol (polar solvent) was the least effcient. Ethanol showed\nvery poor signal for the most saturated TAGs, while dichloromethane showed the lowest percentages\nof DAGs. Accordingly, the screening of the total fatty acid composition revealed the lowest percentage\nof linoleic acid (C18:2n6) in the dichloromethane extract, which instead contained the highest\namount (greater than 60%) of oleic acid (C18:1n9). Polyphenolic compounds with pharmacological\neects (anti-tumor, anti-coagulant, and inflammatory), such as coumarin derivative and amygdalin,\noccurred at a higher amount in ethyl acetate and ethanol extracts....
Lilium candidum L., known as Madonna, meadow, or white lily, is a bulbous plant from the\nLiliaceae family, originating in the Middle East. L. candidum has been abundantly used in folk medicine\nsince ancient times to relieve a variety of ailments, including age-related diseases, burns, ulcers, and\ncoughs. The aim of this article is to investigate the anti-inflammatory and anti-diabetic activities of\nL. candidum extracts and its active phytochemicals. Some active volatile phytochemicals were identified\nusing gas chromatographyâ??mass spectrometry (GC-MS) analysis. Significant (p < 0.001) anti-diabetic\nproperties of the extracts kaempferol, linalool, citronellal, and humulene were demonstrated by\nan elevation in glucose uptake by adipocytes. The significant (p < 0.01) effect of the plant extracts\nkaempferol, citronellal, and humulene on the secretion of pro-inflammatory cytokines interleukin\n6 (IL-6) and interleukin 8 (IL-8) was demonstrated using enzyme-linked immunosorbent assay.\nAltogether, L. candidum and its rich collection of phytochemicals hold promising medicinal potential,\nand further investigations of its therapeutic prospects are encouraged....
As per the Indian traditional system of medicine, Baccaurea ramiflora stem bark is used for the treatment of constipation. However, no studies have explored the laxative effects of aqueous extract (juice) of Baccaurea ramiflora stem bark which may be due to the lack of availability of this indigenous wild edible plant. The present study was undertaken to investigate the phytochemical constituents and the laxative activity of the stem bark of Baccaurea ramiflora. Fresh stem barks of Baccaurea ramiflora were collected, dried, extracted with water and evaluated by phytochemical analysis for primary and secondary metabolites viz. carbohydrates, alkaloids, glycosides, tannins, phenols, terpenoids, flavonoids, proteins, fixed oils, gums and mucilage. The aqueous extract of the stem bark of Baccaurea ramiflora at doses (200 and 400 mg/kg, p.o) were screened for the laxative activity. The laxative activity was determined by the weight of faeces matter at 8th and 16th hours. The results were compared with standard Senna extract. Phytochemical investigation showed the presence of glycoside, phytosterols, terpenoids, carbohydrate, gums and mucilage in the stem bark. Aqueous extract of the stem bark of Baccaurea ramiflora showed significant laxative activity. The laxative property can be due to the phytochemicals present in the aqueous extract of the stem bark. Phytochemicals reported gave information regarding the various active constituents present in the drug. The laxative property can be due to the phytochemicals present in the aqueous extract of the stem bark. These findings revealed that oral administration of the aqueous extract of the stem bark of Baccaurea ramiflora produce a significant increase in fecal output in wistar rats and stimulation of gastrointestinal motility. Moreover, isolation of the active principle is required to identify the compound responsible for laxative activity....
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